However, the pain of puncturing the skin with a needle may make it difficult to perform the procedure itself, particularly in children. The registration number is UMIN000011463.īlood sampling is an essential procedure in medical practice. ![]() ![]() Both creams were effective without clinically serious side effects. This randomized crossover trial showed that there was no significant analgesic difference between EMLA® cream and LMX5® cream. No adverse reactions that could be clinically problematic were observed with either cream. There were also no marked differences in secondary outcomes between EMLA® cream and LMX5® cream. There were no significant differences between EMLA® and LMX5® cream after adjusting for participants’ background characteristics, including age and sex (difference: 2.83 95% confidence interval: −11.25 to 16.92 P value: 0.693). We conducted a multivariate regression analysis for the VAS score after adjusting for participants’ background characteristics while also adjusting for clustering of arm-treatment protocols within individuals using a generalized estimating equation. The secondary outcomes were blood sampling site, blood sampling volume, blood sampling frequency, and occurrence of side effects. The primary outcome was each subject’s VAS score (range 0 to 100) for pain during blood sampling. This crossover trial enrolled 24 healthy adult participants randomly assigned to 4 groups by combining 2 formulations of anesthetics and different left-right arm-treatment protocols. We conducted a double-blinded randomized crossover trial to evaluate the analgesic effects of these two creams in healthy adults using a visual analogue scale (VAS). To our knowledge, no study has directly compared the analgesic effects for venipuncture between EMLA® cream and LMX5® cream. Preparations of 2.5% lidocaine plus 2.5% prilocaine cream (trade name EMLA® cream) or 5% lidocaine cream (trade name LMX5® cream) are used for local anesthesia. Medical Support Center for the Japan Environment and Children’s Study, National Center for Child Health and Development Allergy Center, National Center for Child Health and DevelopmentĪllergy Center, National Center for Child Health and DevelopmentĬenter for Postgraduate Education and Training, National Center for Child Health and Development Medical Support Center for the Japan Environment and Children’s Study, National Center for Child Health and Development Center for Postgraduate Education and Training, National Center for Child Health and Development
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